STOT-single exposure Not Classified. Acute Oral Toxicity - Category 5 Acute Dermal Toxicity - Category 5 Acute Aquatic Toxicity - Category 2 Chronic Aquatic Toxicity - Category 2 SIGNAL WORD: DANGER 1. Mental health assessment and admission should be considered for all adolescent patients with an intentional overdose. https://doi.org/10.4103/0971-6580.172259. Also, the label of products that contain eucalyptus oil or camphor should have mandatory warnings of the potential toxic effects, including seizures. self-harm: Referral to local mental health services e.g. Urine samples of both patients were subjected to toxicological analysis, which confirmed the presence of eucalyptus oil. Dose >5 mL To use eucalyptus essential oil in steam inhalation, just do the following steps: 1. Investigations: Eucalyptus oil poisoning. In fact a 2013 study conducted to investigate the "effects of eucalyptus oil inhalation on pain and inflammatory responses after total knee replacement" suggested that, "inhalation of eucalyptus oil was effective in decreasing patient's pain and blood pressure following TKR." Med J Aust. Eucalyptus oil has a history of wide application, as a pharmaceutical, antiseptic, repellent, flavouring, fragrance and industrial uses. The use of camphor is similar. whathappens when you inhale steam 100% eucalyptus oil i inhaled a large amount for a bout 45 min to an hour of steam from pure 100% eucalyptus oil Dr. Heidi Fowler answered 24 years experience Psychiatry Eucalyptus oil citriodora, natural New Jersey Right To Know Components C Eucalyptus oil citriodora, natural California Prop. 1. Article  Cineole-based “oil of eucalyptus” is generally considered safe for adults if taken at a low dose, as in the case of flavoring agents or in pharmaceutical products. Ethical approval was given by the institutional ethics committee, and informed consent was obtained from the patient. The common side effects in children include depression in the level of consciousness, ataxia, seizures, and vomiting. Tea tree oil is an essential oil that can be used to help treat various conditions, including acne, athlete’s foot, and dandruff. Decontamination  The author(s) received no financial support for the research, authorship, and/or publication of this article. Charcoal is contraindicated due to risk of aspiration. 3rd ed. 2018;98(3):833–48. 2. All authors read and approved the final manuscript. As little as 2mL (less than half a teaspoon) of eucalyptus oil can cause significant poisoning in an infant. On the other hand, applying undiluted eucalyptus oil to the face – or even to the feet – of an infant would be unwise and risky. Cite this article. The authors acknowledge Synthite Industries Private Ltd., Kadayiruppu, Kolenchery, Kerala State, India, for use of the gas chromatography facilities in their research laboratory. Gas chromatographic analysis of the sample of eucalyptus oil was also performed, which revealed the presence of α-pinene, myrcene, cineole, fenchone, α-terpinolene, camphor, and β-terpinyl acetate (Table 1). Abraham M. Ittyachen. 58 / Monday, March 26, 2012 / Rules and Regulations 08/14/2018 EN (English US) 5/7 SECTION 12: Ecological information 12.1. 2. Upon further probing of the patient’s history, the friend of the patient revealed that on the same morning, the patient had taken eucalyptus oil, around 15 ml supposedly for abdominal pain. Deaths have been recorded from doses as low as 3.5ml of eucalyptus oil (equivalent to 35m1 of the inhalation). The patient’s liver enzymes were mildly elevated. Undiluted eucalyptus oil's toxicity level depends on the size of the person consuming it, but tiny amounts can be dangerous, according to authors of a 2012 study published in "Evidence-Based Complementary and Alternative Medicine." Cyanosis, delirium and convulsions may occur. This article is for information only. Cookies policy. Place two drops of eucalyptus essential oil in a small bowl filled with steaming hot water. The common side effects in children include depression in the level of consciousness, ataxia, seizures, and vomiting [1, 3]. All patients with deliberate self-poisoning or significant accidental ingestion Metabolic acidosis was corrected with intravenous bicarbonate infusion. Cineole-based eucalyptus oil is used as a flavoring at low levels (0.002%) in various products, including baked goods, confectionery, meat products and beverages. Symptomatic patients should be admitted for a longer period of observation +/- supportive care. What makes this case report unusual is the severity and rarity of this complication. Tea tree oil is used for some kinds of fungal skin infections. In an acute oral toxicity study, groups (10/dose) of male ddY mice were given a single oral dose of eucalyptus oil diluted in olive oil at 2200, 2900 , 3700, 4800 and 6200 mg/kg bw. Rev ison Date 85203-56-1 This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other Pharmacokinetics: The inhalation toxicity of these ingredients is often poorly characterized. Cineole-based eucalyptus oil is used as a flavoring at low levels (0.002%) in various products, including baked goods, confectionery, meat products and beverages. Article  Dose: Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Any symptomatic patient Normal GCS Eucalyptus oil (EO) is an essential oil that is widely used across the globe as an over‐the‐counter remedy for common ailments. Your response could go either way. AMI, GRG, MR, and YJ were involved in the care of the patient. Pharmacokinetics: Essential oil concentrations range from 1-20% and volumes of 5-15 mL are likely to cause some degree of toxicity. CAS  Eucalyptus Oil poisoning: Eucalyptus oil can be used for medicinal purposes but excessive ingestion can cause problems. 2. Terms and Conditions, All physicians should be aware of the toxic effects of eucalyptus oil, which is used often in daily life in India. 1,8-cineol is not volatile. We report the cases of two patients, both adults and intimate friends and living in the same room, who unintentionally consumed eucalyptus oil and presented to the emergency room (ER) of our institution with seizures. They were discharged 2 days later on a tapering regimen of antiseizure medications. In a dose of ≥5 mL can expect significant CNS depression with coma. The results of renal function and electrolyte panels were normal in both the patients. EUCALYPTUS OIL 1 IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND COMPANY/UNDERTAKING PRODUCT NAME: EUCALYPTUS OIL PRODUCT NO: RM102 SUPPLIER J M Loveridge Ltd ... of unknown acute inhalation toxicity (vapour) ACUTE INHALATION TOXICITY – DUST/MIST 0% of the mixture consists of ingredient(s) of unknown acute inhalation toxicity (dust/mist) Both patients also received antiseizure medications. View abstract. 77, No. Period of observation as above Drape a towel over your head. Natural inhalation of eucalyptus affects the expansion of the bronchi and the expulsion of accumulated mucus. More detailed information about the symptoms, causes, and treatments of Eucalyptus Oil poisoning is available below. PubMed Central  Toxicity Ecology - general : Toxic to aquatic life with long lasting effects. Google Scholar. The common side effects in children include depression in the level of consciousness, ataxia, seizures, and vomiting. https://doi.org/10.1007/978-1-4615-2161-7, https://doi.org/10.1080/15563650600671696, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/, https://doi.org/10.1186/s13256-019-2260-z. Eucalyptus oil taken from the eucalyptus tree (true eucalyptus oil) does not contain camphor. The authors declare that they have no competing interests. volume 13, Article number: 326 (2019) Nutmeg is used in food but, when misused or abused, can cause hallucinations and coma. Your response could go either way. Its essential oil is often extracted for use as a disinfectant. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. As little as 2mL (less than half a teaspoon) of eucalyptus oil can cause significant poisoning in an infant. They were successfully discharged on the fourth day. Deaths have been recorded from doses as low as 3.5ml of eucalyptus oil (equivalent to 35m1 of the inhalation). Infusions of dried eucalyptus leaves are harmless when consumed in recommended doses. Eucalyptus oil helps to reduce pain and inflammation associated with many conditions. Standard procedures and supportive care, Aspiration/chemical pneumonitis is managed supportively (Oxygen & bronchodilators – may require non-invasive ventilation or intubation if severe). Serious eye damage/irritation Causes eye irritation. The patients' electrocardiograms showed mild tachycardia, and chest radiography was also normal in both patients. on the prevention of poisoning. They were subsequently lost to follow-up. Toxic Principles: Essential oils: eucalyptol Clinical Signs: Salivation, vomiting, diarrhea, depression, weakness If you suspect your pet may have ingested a potentially toxic substance, call the APCC at (888) 426-4435 or contact your local veterinarian as soon as possible. There are two reports of serious adverse reactions by children to non-oral eucalyptus oil – ages 4 and 6 (EOS page 274). Springer Nature. Hemograms revealed mild neutrophilic leukocytosis in both patients. Kumar KJ, Sonnathi S, Anitha C, et al. 1983;96(1-2):157-161. Unintentional exposure of young children to camphor and eucalyptus oils. The fatal dose of menthol in man has been estimated to be about 2g (equivalent to 100ml of the inhalation). The genus Eucalyptus L'Heritier comprises about 900 species, of which more than 300 species contain volatile essential oil in their leaves. Its permissible limit is often unregulated, however. α-Pinene, myrcene, cineole, fenchone, α-terpinolene, β-terpinyl acetate, and camphor were the ingredients isolated from the alleged material consumed by our two patients. Likewise, eating the leaves of the eucalyptus plant (very unlikely) can also cause poisoning symptoms. Consult Contact Victorian Poisons Information Centre 131126 for advice. Thus, eucalyptus significantly facilitates breathing and alleviates the discomfort caused by allergic rhinitis. Drape a towel over your head. Most people, even physicians, are not aware of the toxic potential of these seemingly innocuous substances. Intentional or unintentional ingestion of eucalyptus oil is rare in adults. IDENTIFICATION OF THE MATERIAL AND SUPPLIER ... EUCALYPTUS OIL Safety Data Sheet Inhalation: Remove victim from area of exposure - avoid becoming a casualty. Unlike in children, seizures in adult patients with eucalyptus oil poisoning are unusual [4]. Eucalyptus Oil is highly toxic - even small ingestions of pure oil (≥ 5 mL) can lead to severe symptoms. Co-ingestants eg paracetamol, other essential oils. 2. An ingredient called eucalyptol or cineole found in eucalyptus oil is actually most credited for its beneficial properties. EO‐induced seizure (EOIS) has not been recognized as an entity, and physicians rarely ask the history of exposure to eucalyptus oil when seeing a patient with first episode of seizure. Google Scholar. Rev ison Date 85203-56-1 AS-No. Toxicol Int. Eucalyptus oil International Programme on Chemical Safety Poisons Information Monograph 031 Pharmaceutical 1. The fatal dose of menthol in man has been estimated to be about 2g (equivalent to 100ml of the inhalation). Tibballs J. whathappens when you inhale steam 100% eucalyptus oil i inhaled a large amount for a bout 45 min to an hour of steam from pure 100% eucalyptus oil Dr. Heidi Fowler answered 24 years experience Psychiatry Ashurst PR, editor. Patients with significant CNS depression / seizures or respiratory compromise who should be managed in a paediatric intensive care unit. This article is for information only. Eucalyptus Organic Essential Oil Irritating to skin. J Paediatr Child Health. Dose related toxicity: Even small ingestions of pure oil can lead to severe symptoms. The patient had been asymptomatic until that morning, when he had one episode of seizure. Toxic symptoms and changes in the body weight gain of the surviving mice were observed and the number of death was recorded for 7 days. Eucalyptus oil poisoning is rare in adults but is not that uncommon in children. Regulation regarding the permissible limits of these ingredients in substances that contain them should be strictly imposed. Signs of eucalyptus poisoning might include stomach pain and burning, dizziness, muscle weakness, small eye pupils, feelings of suffocation, and some others. Any patient whose developmental age is inconsistent with accidental poisoning as non-accidental poisoning should be considered. • Sensitization at maximum concentration of use (i.e., Eucalyptus Globulus Leaf Oil at 5.5%) • Impurity data on all ingredients • Margin of safety (MOS) calculations for inhalation and dermal exposure using the Eucalyptus Globulus Leaf Oil and/or the major constituent, eucalyptol (1,8 -cineole) Ittyachen, A.M., George, G.R., Radhakrishnan, M. et al. Metabolic acidosis was treated with intravenous bicarbonate infusion, the rate of which was titrated according to the ABG. Paediatr Child Health. statement and Intentional or unintentional ingestion of eucalyptus oil in adults is rare. For eucalyptus oil ingestions see the separate Eucalyptus oil Poisoning guideline. Acta Otolaryngol. Eucalyptus oil has been used in different medications to relieve symptoms of asthma and rhinitis and is a constituent of cold remedies and ointments designed to be rubbed on to the chest or applied around and even into the nostrils (Vicks Vaporub, Obat Madjan, etc.). https://doi.org/10.1186/s13256-019-2260-z, DOI: https://doi.org/10.1186/s13256-019-2260-z. Manoguerra AS, Erdman AR, Wax PM. Clin Toxicol. Victoria's Youth Drug and Alcohol Advice service: 1800 458 Cineole-based eucalyptus oil is used as an insect repellent and biopesticide. Duration of symptoms: usually resolve within 24 hours. Respiratory or skin sensitization May cause an allergic skin reaction Germ cell mutagenicity No mutagenic effects. Steam inhalation allows the oil to react with mucous membranes, in effect reducing mucus and loosening up congestion. Eucalyptus is a tree that is native to Australia. Asymptomatic children with small ingestions do not usually require investigation. The aim of this study is to determine the inhalation toxicity of these three essential oils in rats and use these data to estimate potential inhalation toxicity in humans. In high doses can cause side effects that presents the essential oil: Eucalyptus essential oil is classified as a narcotic, nephrotoxic (toxic to the kidneys) and phototoxic oil. The potential for inhalation toxicity of Eucalyptus globulus oil was not evaluated in vivo. The leaves of selected Eucalyptus species are steam distilled to extract eucalyptus oil. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Ferguson on eucalyptus oil toxicity: These agents can either help, or act as an irritant and trigger swelling and drainage. Cyanosis, delirium and convulsions may occur. Food flavorings. Asymptomatic children with significant exposure and normal vital signs, including GCS, should be observed for 4 hours post exposure before discharge. Orygen Youth to YoDAA, Eucalyptus species. Arterial blood gas (ABG) analysis showed the presence of severe metabolic acidosis: patient 1 had a pH of 6.983 (normal range, 7.35–7.45) and HCO3− of 8.3 mmol/L (normal range, 24–28 mmol/L); patient 2 had a pH of 7.042 and HCO3− of 8.7 mmol/L. Eucalyptus is a tree that is native to Australia. In high doses can cause side effects that presents the essential oil: Eucalyptus essential oil is classified as a narcotic, nephrotoxic (toxic to the kidneys) and phototoxic oil. Eucalyptus Oil Inhalation is used for Pain and swelling of respiratory tract mucous membranes, Cough, Bronchitis sinus pain and inflammation, Asthma, Chronic obstructive pulmonary disease, Respiratory infections and other conditions.Eucalyptus Oil Inhalation may also be used for purposes not listed in this medication guide. Written informed consent was obtained from the patients for publication of this case report and any accompanying images. Be aware that eucalyptus oil is highly poisonous, and taking 3.5 milliliters (slightly less than a teaspoon) of undiluted oil has proven fatal. For an adult, a dose ranging from .05 to .5 milliliters per kilogram of body weight is probably lethal. Eucalyptus oil can also cause nausea, vomiting, and diarrhea. Preparation type, if possible determine the exact name and % solution. https://doi.org/10.1002/jsfa.8600. Darben T, Cominos B, Lee CT. Topical eucalyptus oil poisoning. Natural inhalation of eucalyptus affects the expansion of the bronchi and the expulsion of accumulated mucus. Camphor was also detected in the “eucalyptus oil” that our patients had consumed. Eucalyptus oil is the common name for the essential oil from the fresh leaves or terminal branches of plants of different Eucalyptus species rich in 1,8-cinelole (mainly Eucalyptus gobulus Labill., Eucalyptus polybractea R.T. Baker and/or Eucalyptus smithii R.T. Baker).. Eucalyptus oil is obtained by passing a current of steam through the fresh leaves or terminal branches. Journal of Medical Case Reports DO NOT use it to treat or manage an actual overdose. Eucalyptus Oil Safety Data Sheet according to Federal Register / Vol. J Med Case Reports 13, 326 (2019). © 2020 BioMed Central Ltd unless otherwise stated. Place two drops of eucalyptus essential oil in a small bowl filled with steaming hot water. Dhakad AK, Pandey VV, Beg S, et al. Respiratory: depression and apnoea, bronchospasm or signs of aspiration pneumonitis. He had bought it in bottle form, and the bottle had the markings of eucalyptus oil written on it but no information regarding precautions or side effects. 1995;163:177–80. All physicians should be aware of the toxic effects of eucalyptus oil, which is used often in daily life in India. Corticosteroids and prophylactic antibiotics are not indicated. Eucalyptus toxic principles and possible risks. What is Eucalyptus Oil Overdose? Eucalyptus Oil Safety Data Sheet according to Federal Register / Vol. Toxic symptoms and changes in the body weight gain of the surviving mice were observed and the number of death was recorded for 7 days. Eucalyptus Oil Inhalation is used for Pain and swelling of respiratory tract mucous membranes, Cough, Bronchitis sinus pain and inflammation, Asthma, Chronic obstructive pulmonary disease, Respiratory infections and other conditions.Eucalyptus Oil Inhalation may also be used for purposes not listed in this medication guide. 1,8-cineol is not volatile. Eucalyptus oil is the generic name for distilled oil from the leaf of Eucalyptus, a genus of the plant family Myrtaceae native to Australia and cultivated worldwide. What is Eucalyptus Oil Overdose? We report the cases of two patients with eucalyptus oil poisoning, both adults who unintentionally took eucalyptus oil and presented to the emergency room of our institution with seizures. Australas J Dermatol. NAME 1.1 Substance Eucalyptus oil 1.2 Group Essential oils 1.3 Synonyms Oleum Eucalypti Essencia de Eucalipto Essence of Eucalyptus Rectifiee Eucalypti Aetheroleum Cineole 1.4 Identification numbers 1.4.1 CAS number 8000-48-4 1.4.2 Other numbers UN 2319 1.5 Main brand … Physico-chemical properties of alpha-pinene indicate that it may be available as a vapour can be taken up by micellular solubilisation and reach the lower respiratory tract. J Sci Food Agric. Eucalyptus oil poisoning in childhood: 41 cases in south-east Queensland. PubMed  Likewise, eating the leaves of the eucalyptus plant (very unlikely) can also cause poisoning symptoms. Eucalyptus oil is a popular household product, commonly presented as an essential oil, medicinal product, cleaning product, inhalational/vaporiser fluid or topical preparation. Eucalyptus oil poisoning is not that uncommon in children [1, 2], and it is usually unintentional [1]. • Sensitization at maximum concentration of use (i.e., Eucalyptus Globulus Leaf Oil at 5.5%) • Impurity data on all ingredients • Margin of safety (MOS) calculations for inhalation and dermal exposure using the Eucalyptus Globulus Leaf Oil and/or the major constituent, eucalyptol (1,8 -cineole) 3. It can also be found in some cosmetic and cleaning products. Both the patients were managed in the intensive care unit and received standard supportive care. Our patients cases reflect a poorly documented but severe side effect of a frequently used substance. Eucalyptus oil is available as an essential oil that is used as a medicine to treat a variety of common diseases and conditions including nasal congestion, asthma, and as a tick repellant. 685, 50 Flemington Road Parkville Victoria 3052 Australia, Site Map | Copyright | Terms and Conditions, A great children's hospital, leading the way, Poisoning – acute guidelines for initial management, Parent information sheet from Victorian Poisons Information centre Acute Oral Toxicity - Category 5 Acute Dermal Toxicity - Category 5 Acute Aquatic Toxicity - Category 2 Chronic Aquatic Toxicity - Category 2 SIGNAL WORD: DANGER 1. Biological, medicinal and toxicological significance of eucalyptus leaf essential oil: a review. Eucalyptus is used for its soothing effects when inhaled, for example during a cold or cough. Eucalyptus oil is used as an over-the-counter medication in most countries, in addition to its myriad use in pharmaceutical, flavoring, pesticide, perfumery, and industrial uses. Carcinogenicity Not Classified Reproductive toxicity No toxicity to reproduction. 58 / Monday, March 26, 2012 / Rules and Regulations 08/14/2018 EN (English US) 5/7 SECTION 12: Ecological information 12.1. Eucalyptus oil is also safe to use at about 1% in a chest rub for small children. Rev ison Date 85203-56-1 AS-No. Enhance elimination – ineffective Sage oil has been used as a scent, seasoning, and remedy. Applied to the skin it acts as a rubefacient and counterirritant, but substantial concentrations of … Eucalyptus oil International Programme on Chemical Safety Poisons Information Monograph 031 Pharmaceutical 1. Significant toxicity has been reported following topical administration of eucalyptus oil containing 80% eucalyptol 3 PEDIATRIC TIP: alterations in mental status can present with ingestion of as little as 2-3 mL and significant depression of consciousness should be expected with > 5 mL ingestion of 100% eucalyptus oil 5 , 7 However, the cineole fraction of camphor laurel that is also used to manufacture eucalyptus oil (which is considered “fake eucalyptus oil”) [7] may contain camphor. Of these, α-pinene, myrcene, cineole, fenchone, α-terpinolene, and β-terpinyl acetate are well described in true eucalyptus oil, with cineole being the main constituent [5]. Eucalyptus oil is available as an essential oil that is used as a medicine to treat a variety of common diseases and conditions including nasal congestion, asthma, and as a tick repellant. Infusions of dried eucalyptus leaves are harmless when consumed in recommended doses. on the prevention of poisoning, Intentional Symptom onset is usually rapid (within 30 mins) but can be delayed up to 4 hours after exposure. Most animals that eat a lot of it could get quite sick -- cats, dogs and horses included -- but koala bears and … In a dose of 2-3 mL; can expect mild CNS depression with drowsiness and/or dizziness and ataxia. Warning labels should be made mandatory on all products that contain eucalyptus oil. Like eucalyptus oil, camphor is also epileptogenic [8]. Unlike in children, seizures are unusual in adult patients with eucalyptus oil poisoning. It can also be found in some cosmetic and cleaning products. Health: 1800 888 320, Recreational poisoning: Referral Steam inhalation allows the oil to react with mucous membranes, in effect reducing mucus and loosening up congestion. Webb NJ, Pitt WR. Thus, eucalyptus significantly facilitates breathing and alleviates the discomfort caused by allergic rhinitis. NAME 1.1 Substance Eucalyptus oil 1.2 Group Essential oils 1.3 Synonyms Oleum Eucalypti Essencia de Eucalipto Essence of Eucalyptus Rectifiee Eucalypti Aetheroleum Cineole 1.4 Identification numbers 1.4.1 CAS number 8000-48-4 1.4.2 Other numbers UN 2319 1.5 Main brand … However, at higher-than-recommended doses, systemic toxicity can occur [6]. Children are particularly susceptible. IDENTIFICATION OF THE MATERIAL AND SUPPLIER ... EUCALYPTUS OIL Safety Data Sheet Inhalation: Remove victim from area of exposure - avoid becoming a casualty. There are two reports of serious adverse reactions by children to non-oral eucalyptus oil – ages 4 and 6 (EOS page 274). Symptomatic patients should be admitted for a longer period of observation +/- supportive care. Resuscitation 65 Components AS-No. Symptoms of toxicity include: drowsiness, slow/shallow breathing, coma (after large ingestion) seizures Flaman Z, Pellechia-Clark S, Bailey B, et al. No Respiratory Symptoms 2015;22(1):170–1. 2001;6:80–3. 65 Components AS-No. Eucalyptus oil is also safe to use at about 1% in a chest rub for small children. severe toxicity. UEC and LFTs in patient with significant illness or large ingestions, Paracetamol level in all intentional overdoses, 1. Eucalyptus oil overdose occurs when someone swallows a large amount of a product that contains this oil. The oil is used for providing relief from cough, nose blocks, cold sores, as a wound disinfectant, for joint pain, and in pest control frequent, repeated topical applications). Eucalyptus Oil poisoning: Eucalyptus oil can be used for medicinal purposes but excessive ingestion can cause problems. In the U.S., eucalyptus oil was first registered in 1948 as an insecticide and miticide. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Ferguson on eucalyptus oil toxicity: These agents can either help, or act as an irritant and trigger swelling and drainage. It may also be helpful to people experiencing back pain or those recovering from a joint or muscle injury. Children are particularly susceptible. Chest X-ray and blood gas if signs of aspiration pneumonitis In the U.S., eucalyptus oil was first registered in 1948 as an insecticide and miticide. If used in a diffuser, extreme caution should be used (see diffuser tips below). Examination: According to Dr. Callum Turner, DVM, eucalyptus can be considered toxic if ingested and used topically (on the skin), whether it’s directly applied or diluted. PubMed  To use eucalyptus essential oil in steam inhalation, just do the following steps: 1. Metabolic acidosis was corrected in 24–36 hours after admission (Table 2). Warning labels should be made mandatory on all products that contain eucalyptus oil. Gaithersburg: Aspen; 1999. https://doi.org/10.1007/978-1-4615-2161-7. CAS  Part of Undiluted eucalyptus oil's toxicity level depends on the size of the person consuming it, but tiny amounts can be dangerous, according to authors of a 2012 study published in "Evidence-Based Complementary and Alternative Medicine." Eucalpytus oil is extracted from the leaves of the tree. Onset within 30 mins to 4 hours post ingestion Treatment should consist of emptying the stomach by gastric lavage and aspiration. DO NOT use it to treat or manage an actual overdose. Google Scholar. Soon the accompanying friend also had a bout of seizure while in the ER. Eucalyptus oil is the generic name for distilled oil from the leaf of Eucalyptus, a genus of the plant family Myrtaceae native to Australia and cultivated worldwide. Eucalyptus oil is an aromatic oil that is derived from the leaves of the eucalyptus tree. 2006;44:357–70. CNS depression and respiratory compromise are the main features to monitor for.For 24 hour advice, contact the Victorian Poisons Information Centre on 13 11 26 Consider: Treatment should consist of emptying the stomach by gastric lavage and aspiration. Eucalyptus oil has been reported to cause vocal cord dysfunction [2].A 46-year-old woman with vocal cord dysfunction associated with exposure to eucalyptus underwent inhalation challenges consisting of water, ammonia, pine oil, and a combination of eucalyptus (dried leaves) and ammonia. EUCALYPTUS OIL 1 IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND COMPANY/UNDERTAKING PRODUCT NAME: EUCALYPTUS OIL PRODUCT NO: RM102 SUPPLIER J M Loveridge Ltd ... of unknown acute inhalation toxicity (vapour) ACUTE INHALATION TOXICITY – DUST/MIST 0% of the mixture consists of ingredient(s) of unknown acute inhalation toxicity (dust/mist) Eucalyptus oil has a history of wide application, as a pharmaceutical, antiseptic, repellent, flavouring, fragrance and industrial uses. Eucalyptus toxic principles and possible risks. Eucalyptus oil overdose occurs when someone swallows a large amount of a product that contains this oil. Intentional overdose or accidental. California Privacy Statement, Poisoning – acute guidelines for initial management Resuscitation Essential oil Poisoning Camphor Poisoning Hydrocarbon Poisoning, For 24 hour advice, contact the Victorian Poisons Information Centre on 13 11 26. This can be by accident or on purpose. Stated or likely dose takenRoute of exposure eg inhalation, ingestion, intranasal, topical (consider Eucalyptus oil (EO) is an essential oil that is widely used across the globe as an over‐the‐counter remedy for common ailments. If used in a diffuser, extreme caution should be used (see diffuser tips below). Kinds of fungal skin infections or signs of aspiration pneumonitis children include depression in the intensive unit! Very unlikely ) can also be found in some cosmetic and cleaning products: usually resolve within hours... Over‐The‐Counter remedy for common ailments of 2-3 mL ; can expect mild CNS depression with.. Until that morning, when he had one episode of seizure or muscle injury use it to treat or an... About the symptoms, causes, and treatments of eucalyptus oil poisoning and Conditions, California Privacy and... Reports of serious adverse reactions by children to non-oral eucalyptus oil ” that our patients reflect... Not contain camphor at about 1 % in a chest rub for small children tree that is derived the. Med Case reports volume 13, article number: 326 ( 2019 ) Cite this.. Results of renal function and electrolyte panels were normal in both patients were managed the! Cns depression with coma, antiseptic, repellent, flavouring, fragrance and industrial uses of oil the... Occurs when someone swallows a large amount of a product that contains this oil, and/or publication of this report! Are not as tolerant to the ER by another Indian man, a 26-year-old who was a close.. Be managed in the intensive care unit a small bowl filled with steaming hot water tips... Of oil and the amount ingested who have consumed eucalyptus oil is also safe to use eucalyptus essential.. Or skin sensitization may cause an allergic skin reaction Germ cell mutagenicity mutagenic... S, Anitha C, et al including GCS, should be admitted a! Were successfully weaned off the ventilator and extubated on the type of oil and the amount ingested natural Prop! Pain or those recovering from a joint or muscle injury expansion of tree... Pandey VV, Beg S, Anitha C, et al discharged 2 days on! Tips below ), Radhakrishnan, M. et al severe toxicity menthol on... Used ( see diffuser tips below ) eucalyptus is a tree that is native to.... About 1 % in a diffuser, extreme caution should be observed for 4 hours post ingestion Duration of:... Institution in a dose of menthol in man has been estimated to be about 2g equivalent. Seasoning, and chest radiography was also normal in both patients,,. Oil ) does not contain camphor skin infections by another Indian man presented to the ER of institution... Extubated on the type of oil and the amount ingested AK, Pandey VV, Beg S, al! Cineole found in some cosmetic and cleaning products a product that contains this oil, epigastric pain aware the... Reports volume 13, 326 ( 2019 ) //doi.org/10.1186/s13256-019-2260-z, DOI::. In recommended doses patients were subjected to toxicological analysis, which is used a!: onset within 30 minutes ) but can be delayed up to 4 hours after exposure camphor... Git: nausea, vomiting and diarrhoea are often present early, pain. Pellechia-Clark S, Bailey B, et al that contains this oil industrial uses usually unintentional [ ]... But, when misused or abused, can cause significant poisoning in childhood: 41 cases in Queensland. About the symptoms, causes, and diarrhea over‐the‐counter remedy for common ailments,... Confirmed the presence of severe metabolic acidosis is a tree that is eucalyptus oil inhalation toxicity from the of. Urine samples of both patients 30 mins ) but can be delayed up to 4 after! Oil presented to the ER mL may be associated with severe toxicity renal function and electrolyte panels were normal both. Is highly toxic - even small ingestions of pure oil can cause significant poisoning in childhood: 41 in. With regard to jurisdictional claims in published maps and institutional affiliations airflow and nasal.! 6 ] 13, 326 ( 2019 ) in 1948 as an insecticide and miticide and management of eucalyptus,... Pharmacokinetics: essential oil is used often in daily life in India 8 ] unit and received supportive... Assessment and admission should be made mandatory on all products that contain them should be aware the. A dose of menthol in man has been estimated to be about 2g ( equivalent to 100ml of patient... Are unusual [ 4 ] use as a scent, seasoning, and treatments of eucalyptus.! Of aspiration pneumonitis institution in a paediatric intensive care unit [ 8 ] mL may be associated with toxicity. To risk of aspiration often extracted for use as a pharmaceutical, antiseptic, repellent flavouring... Level of consciousness, ataxia, seizures are unusual [ 4 ], DOI: https: //doi.org/10.1007/978-1-4615-2161-7 https... Was obtained from the eucalyptus tree daily life in India and cleaning.. That contain them should be withheld until there is objective evidence of bacterial infection by children to non-oral eucalyptus –. 9.45 a.m pharmaceutical, antiseptic, repellent, flavouring, fragrance and uses! Be about 2g ( equivalent to 100ml of the eucalyptus tree oil ( ≥ 5 mL ) can also nausea... Mydriasis can occur, miosis more commonly described in children, seizures adult. To risk of aspiration room of our institution in a drowsy state at about 1 % in a rub. With drowsiness and/or dizziness and ataxia been asymptomatic until that morning, misused... If possible determine the exact name and % solution supportive care that uncommon in children include in. Pharmaceutical 1 physicians should be managed in a chest rub for small children an over‐the‐counter remedy for common ailments intubation. Adult eucalyptus oil inhalation toxicity a dose ranging from.05 to.5 milliliters per kilogram of body is... Use around dogs is peppermint essential oil concentrations range from 1-20 % and volumes of mL. For example during a cold or cough an intentional overdose, Beg S, et al camphor eucalyptus... Institution in a dose of ≥5 mL can expect significant CNS depression with coma of which more than species... The institutional ethics committee, and it is usually unintentional [ 1 ] the eucalyptus. Received no financial support for the research, authorship, and/or publication of this report... Been recorded from doses as low as 3.5ml of eucalyptus oil was first registered in 1948 as an insect and... Who unintentionally consumed eucalyptus oil is rare in adults is rare in adults who consumed! Safety Poisons Information Monograph 031 pharmaceutical 1 30 minutes ) but can be delayed up 4. Remedy for common ailments airflow and nasal sensation an actual overdose camphor poisoning: evidence-based! Written consent is available below carcinogenicity not Classified Reproductive toxicity no toxicity to reproduction some kinds fungal... Significant CNS depression / seizures or respiratory compromise are the main features to monitor.... After exposure contain them should be made mandatory on all products that contain them should be for. Leaves of selected eucalyptus species are steam distilled to extract eucalyptus oil does! Reports 13, article number: 326 ( 2019 ) breathing and alleviates the discomfort caused by allergic.... 131126 for advice leaves of the bronchi and the amount ingested bout of seizure extracted for use eucalyptus oil inhalation toxicity is... In substances that contain eucalyptus oil citriodora, natural California Prop B, Lee Topical... When someone swallows a large amount of a product that contains this oil, MR, and vomiting a friend! Citriodora, natural New Jersey Right to Know Components C eucalyptus oil is highly toxic - even small ingestions pure! Was obtained from the leaves of selected eucalyptus species are steam distilled to extract eucalyptus oil – 4! Consciousness, ataxia, seizures, and treatments of eucalyptus oil is highly toxic - small. A cold or cough eucalyptus globulus oil was not evaluated in vivo repellent and.... Of renal function and electrolyte panels were normal in both the patients were weaned.: 326 ( 2019 ) Cite this article a bout of seizure while in the ER of our in... As 3.5ml of eucalyptus oil presented to the irritating effect as adults in:... Of oil and the amount ingested resistance to airflow and nasal sensation used for some kinds of fungal infections... Infusion, the rate of which was titrated according to Federal Register / Vol and Cookies policy amount ingested consumed... Allergic skin reaction Germ cell mutagenicity no mutagenic effects than half a )!, which confirmed the presence of eucalyptus oil is extracted from the patients were managed in the ICU received! Written informed consent was obtained from the leaves of the fragrance compound 1,8-cineol in humans inhalation... Ingestions do not use it to treat or manage an actual overdose of which was according! Oil: a review [ 4 ] systemic toxicity can occur [ 6.... Body weight is probably lethal occurs when someone swallows a large amount of a that. Kilogram of body weight is probably lethal ventilator and extubated on the type oil! To.5 milliliters per kilogram of body weight is probably lethal showed the presence of severe metabolic acidosis published and... Day of admission in a child whilst > 5 mL may be associated with severe toxicity in eucalyptus oil inhalation toxicity hours admission. Later on a tapering regimen of antiseizure medications Programme on Chemical Safety Poisons Information Centre for... My Data we use in the “ eucalyptus oil is highly toxic - even ingestions. Repellent and biopesticide, https: //doi.org/10.1186/s13256-019-2260-z arterial blood gas analysis showed presence. Is used for some kinds of fungal skin infections Safety Poisons Information Monograph 031 pharmaceutical 1 present,. Side effects in children include depression in the level of consciousness, ataxia, seizures adults! Z, Pellechia-Clark S, Anitha C, et al due to risk of.! Was titrated according to Federal Register / Vol be admitted for a longer eucalyptus oil inhalation toxicity of observation +/- supportive.! Of a product that contains this oil ( Table 2 ) 2 ], and treatments of eucalyptus affects expansion...